BASIC BIOPHYSICS FOR MOTION IN CELLS
Note the overall Course Statement of Aims and Content, Prerequisites and Texts [see first page].
Course Outline (2003: 27 lectures of 80 min. each with 5 minute break)
| 0 | Introduction |
| 1 | Overview of Molecular Motors |
| 2 | Cells: Eucaryotes and Procaryotes |
| 3 | Observation of Single Molecules |
| 4 | Other motors: Reverse Engineering |
| 5 | About ATP: A Universal Cellular Fuel |
| 6 | Amino Acids, Peptides, Proteins |
| 7 | Mechanical Forces |
| 8 | Mechanical Properites of Proteins |
| 9 | Vicosity of Liquids |
| 10 | Thermal Effects |
| 11 | Brownian Motion and Random Walks |
| 12 | Discrete Time Walks; Generating Functions |
| 13 | Fick's Law and Diffusion |
| 14 | Fokker-Planck Equation |
| 15 | Chemical Rates (Eyring vs. Kramers) |
| 16 | Enzyme Kinetics |
| 17 | Effects of Force |
| 18 | Polymer Mechanics: Bending, buckling, drag. |
| 19 | Persistence Length and Fluctuations |
| 20 | The Elements of the Cytoskeleton |
| 21 | Active Polymerization and Force Generation |
| 22 | Ion Channels (Visiting Lecturer) |
| 23 | Titin & Nebulin in Muscle (Visiting Lecturer) |
| 24 | Structure and Function of Motor Proteins |
| 25 | Re-engineering Motors; Chimeras |
| 26 | Time Scales for Motor Proteins |
| 27 | The Power Stroke Model and Chemical Ratchets |